According to a recent interview with CD Projekt Red, the upcoming expansion to The Witcher 3, Blood & Wine, will be Geralt's last adventure and writer Jakub Szamalek reportedly believes that the expansion is "something even better than the main game".
One of things CD wanted to do for the expansion was to create a more “charismatic enemy” for Geralt to face, as well as develop a more complex story they believe “players will appreciate.” This is Geralt’s final story according to the interview, so it sounds like CD Projekt RED wants to make it a memorable and lasting experience for players.
Source: OnlySP.