Fallout 4 has scored one of the finest composers in gaming and in general with Inon Zur. Bethesda has published a fantastic interview with Mr. Zur that reveals details about his compositions, the instruments he's to create a unique sound for Fallout 4.
A uniquely modified piano sound is all well and good, but what about that shrill-as -hell garden chair along with all the other banging around? It’s just one of the three major elements that constitute the soundscapes of Fallout: classical instruments; electronic instruments; and a non-musical instrument or an ethnic/primitive instrument. The goal, Zur explains, is for players to hear a particular combination of these instruments and know where they are. “For example, in some parts of the game we decided that the right feel would be more orchestral, but the lead instrument is low accordion,” Zur says. “Other areas, I sampled myself playing this unusual improvised ocarina, which gives all this airiness and shrillness.”
Read the full interview and lend an ear to the two included tracks at the link above. You can also listen to Mr. Zur play the Fallout 4 main theme in the video below.