How to Kill the Fun - Mosignor Plaza Bug Can End Game

According to Gamespot, there is a potentially game-ending bug in a Fallout 4 quest line that takes players to Mosignor Plaza. Traveling to the location causes a desktop crash and pops up an error message.  The bug has been reported on all available platforms (XBox One, PlayStation 4 and PC).

See an apparent work around in action in the video below.