The Mako, both loved and hated by fans of the series, will be present in Mass Effect 4. The vehicle opens up possibilities for open travel across the universe, much as it did in the first title. At last weekend's San Diego Comic Con, the Mass Effect team was on hand to share a bit of concept art, though new details about ME4 were scarce.
Along with the details outlined below, there were a few other details resulting from Comic Con's Mass Effect panel. BioWare confirmed the player character will be human and not one of the many races featured in the game's universe and it's possible the game could occur during Shepard's lifetime. BioWare has confirmed previously, however, that the new Mass Effect will have no connection to Shepard.
Source: Game Informer