Guild Wars Nightfall is the third in a series of stand-alone “campaigns” set in the Guild Wars CORPG universe, following Guild Wars and Guild Wars Factions. Additions include two new professions available beyond the six core professions. They are the Dervish, a holy warrior who wields a scythe, uses many different enhancements and has the ability to temporarily transform into a godly likeness, and the Paragon, a spear throwing support class capable of aiding all nearby allies by shouting and chanting.

Another major addition is the new customizable heroes that take the place of NPC bot henchmen available in the first two campaigns. Unlike henchmen, these heroes level up with the player, follow player instructions, are thoroughly customizable by the player and can even be used in Hero vs. Hero PvP. As with the first two campaigns, purchase of the game allows unlimited free play.