What is the best way to target an opponent , swich targets in combat ?

personally im and avid  'tabber'. since clicking usually results in selecting a random person in the big battle infront of me.

but for more constructive advice, i'd specify on whether you're interested in offensive or defensive targetting, unless you want advice on both.

*woops my mistake, didnt see you said opponent*

theres a comand to target nearest, another for next target and mouse target aswel.. lots of possibilities.

I set Target Nearest to tab, and Target nearest ally to ~ so I can easily switch around if I'm on my healer. Besides that, alot of clicking.

I find a combination of tabbing and select nearest target bound to one of the mouse extra buttons the most effective way, since I play a tank selecting people in the middle of massive zergs by clicking is a big no no.

like most i hit tab like a crazy man digging for gold but if i don't get the target right in front of me doing that i hit Esc real fast clears my target then tab hits the target infront of me 99% of the time.