I think Steelseries is really a hit or miss.  Some people find them the sturdiest mice.  Some people have them crap out on them pretty early.  I think price is probably the deciding factor for Steel Series.  Steel Series made the best mouse pad I have ever used.  However, if you found a product of their's to be crap then there is not point in suggesting one.  They would also probably be on the small side.

Now if you are looking for indestructible, thats a tough one.  Microsoft Mice are usually pretty durable, but I really hate using them.  You can also go the metal mouse look with a Tt eSPORTS Level 10 mouse which is made of aluminum.  It should survive a python.  However, its also a Thermaltake product.  The shell may be very durable and pretty but the electronics usually die.  I have had almost every Thermaltake Fan I have used become unbalanced and make a grinding nois.  However once again I think thats more a price issue as the fans came with the case and were probably around $3.  The mouse is in the high price range so it probably is well built.  Then there is the Corsair Vengeance M65 which might be what you want.

I use the Razer Abyssus

Its the Cheapest razer mouse and has some of the best feel IMO.  Its ambedextrous, or however you spell it, and finally, I think I've even stepped on it a few times... This shit just doesn't breat.  If you're however looking for something super cheep, get a mouse thats around 5$ at a random shop.  It'll last a good 5 years and will never break.  Might feel weird.

All I can contribute is that I use a Razer Death Adder and love it.I realize there may be better mice out there,but I really like the one I have.

I don't believe that any mice are indestructible,where there's a will there's a way.It can be destroyed,as can you :D!

Originally posted by miguksaram

The Mad Catz Cyborg series of mice are some of the sturdiest gaming mice I've owned and they also happen to be some of, if not, the most modular mice on the market.  Based on your OP this series of mice should fit the bill.

http://www.cyborggaming.com/#

Yep got a Cyborg mmo7 - being so adjustable makes it perfect for big hands and it does seem rugged. Recommend trying one at a friends house to see if it meets your strong standards though as its costly.

The chassis and linkages for adjustment are all steel so should do the trick.

Originally posted by punchki

I use the Razer Abyssus

Its the Cheapest razer mouse and has some of the best feel IMO.  Its ambedextrous, or however you spell it, and finally, I think I've even stepped on it a few times... This shit just doesn't breat.  If you're however looking for something super cheep, get a mouse thats around 5$ at a random shop.  It'll last a good 5 years and will never break.  Might feel weird.

Almost.  Ambidextrous. 

I have a Deathadder and have had it for two years.  It's never treated me wrong :)

I've got Logitech MX1000 that still works after 8 years.